Ripoflavin SafeCross Plus

SafeCross®+ 

Riboflavin Solution

Riboflavin solution specifically designed for corneal cross-linking in poor oxygen environment.

Features and Benefits

  • SafeCross®+ a CE-marked riboflavin solution, produced by iVis Technologies, designed for fast penetration and diffusion into the corneal stroma.
  • SafeCross®+ is based on an highly concentrated buffered solution of 0,25% (2,5 mg/mL) riboflavin, 1% (10 mg/mL) hydroxypropyl methyl cellulose, and 0,05% (0,5 mg / mL) EDDS. Its composition is specifically designed to produce an amount of reduced NBT of 0,95 µmol/ml, equivalent to 1,90 µmol/ml of superoxide anion, when it is irradiated with 5,4 J/cm2for 30 minutes at a UV-A 365nm power source of 3 mW/cm2. SafeCross®+ solution is yellow, sterile, highly purified, non-irritating, transparent, with an optimized osmolarity.
  • SafeCross®+ allows to perform a safe cross-linking on thin corneas, allowing the synthesis of cross-linking bridges among the stromal fibers without damaging the corneal endothelium.
  • The percentage of riboflavin available in SafeCross®+ is specifically conceived to minimize the risk of corneal endothelium damage.

 

DESCRIPTION

SafeCross®maximizes the radical activity to support the corneal cross-linking reaction, even in an oxygen-poor environment.

SafeCross®+ composition is specifically designed to produce an amount of reduced NBT of 0,95 µmol/ml, equivalent to 1,90 µmol/ml of superoxide anion, when it is irradiated with 5,4 J/cm2 for 30 minutes at a UV-A 365nm power source of 3 mW/cm2.

SafeCross®+, thanks to its specifically conceived osmolarity, minimizes either the risk of corneal shrinkage and swelling, maximizing the cross-linking bridges activation.

 

For more info: https://www.ivistechnologies.com/products/safecross-plus-riboflavin-solution/

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